Author’s response to reviews Title: Genetic Polymorphisms in Bone Morphogenetic Protein Receptor Type IA Gene predisposes individuals to Ossification of the Posterior Longitudinal Ligament of the Cervical Spine via the Smad signaling pathway
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Title: Genetic Polymorphisms in Bone Morphogenetic Protein Receptor Type IA Gene predisposes individuals to Ossification of the Posterior Longitudinal Ligament of the Cervical Spine via the Smad signaling pathway Authors: hao wang ([email protected]) Wei Jin ([email protected]) Hai Li ([email protected]) Version: 3 Date: 27 Jan 2018 Author’s response to reviews: BMSD-D-17-00981R2 Title: Genetic Polymorphisms in Bone Morphogenetic Protein Receptor Type IA Gene predisposes individuals to Ossification of the Posterior Longitudinal Ligament of the Cervical Spine via the Smad signaling pathway Hao Wang; Wei Tao Jin; Hai Bin Li BMC Musculoskeletal Disorders
منابع مشابه
Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway
BACKGROUND The present study investigated the molecular mechanisms underlying the 4A > C and -349C > T single nucleotide polymorphisms (SNPs) in bone morphogenetic protein receptor type IA (BMPR-IA) gene, which significantly associated with the occurrence and the extent of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine. METHODS The SNPs in BMPR-IA gene were g...
متن کاملA single nucleotide polymorphism in the human bone morphogenetic protein-2 gene (109T > G) affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine.
BACKGROUND Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ligament (OPLL), the etiology of OPLL is not fully understood. The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-2 is a candidate gene to modify...
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The FecB, a mutation in the bone morphogenetic protein receptor IB (BMPR-IB) gene, which increases the fecundity of Booroola Merino sheep, and FecGH, a mutation in the Growth and Differentiation Factor 9 (GDF9), which affects the fecundity of Cambridge and Belclare sheep in a dose sensitive manner, were analyzed as candidate genes associated with the prolificacy in Rayini goats. These polymorph...
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Ossification of the posterior longitudinal ligament (OPLL) is a multi-factorial disease involving an ectopic bone formation of spinal ligaments. It affects 0.8-3.0% aging Asian and 0.1-1.7% aging European Caucasian. The ossified ligament compresses nerve roots in the spinal cord and causes serious neurological problems such as myelopathy and radiculopathy. Research in understanding pathogenesis...
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Ossification of the posterior longitudinal ligament of the cervical spine (OPLL) is characterized by the replacement of ligament tissues with ectopic bone formation, and this result is strongly affected by genetic and local factors. Two single nucleotide polymorphisms (SNPs) of rs2273073 (T/G) and rs235768 (A/T) of bone morphogenetic protein 2 (BMP2) gene which are associated with OPLL have bee...
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